Cutaneous malakoplakia: case report and review

Area of Science:

• Immunodermatology
• Transplant medicine
• Rare diseases

Background:

• Malakoplakia is a rare acquired disorder affecting multiple organ systems, with a predilection for the genitourinary tract.
• Cutaneous manifestations of malakoplakia are exceptionally uncommon.
• The condition is notably more prevalent in patients with compromised immune systems.

Observation:

• This report details a unique case of cutaneous malakoplakia.
• The patient was a kidney transplant recipient.
• The onset of cutaneous malakoplakia occurred shortly after the cessation of immunosuppressive therapy.

Findings:

• The case presented illustrates an unusual occurrence of skin malakoplakia in an immunocompromised patient.
• The patient's history of kidney transplantation and recent discontinuation of immunosuppressants are key factors.
• A review of recent literature on cutaneous malakoplakia in similar contexts was conducted.

Implications:

• This case underscores the importance of considering cutaneous malakoplakia in immunocompromised patients, particularly after changes in immunosuppression.
• It highlights the diagnostic challenges and rarity of skin involvement.
• Further research into the pathogenesis and management of cutaneous malakoplakia in transplant recipients may be warranted.