Neurofibromatosis: chronological history and current issues
João Roberto Antônio1, Eny Maria Goloni-Bertollo, Lívia Arroyo Trídico
1Faculdade Estadual de Medicina, São José do Rio Preto (FAMERP), Hospital de Base, Dermatology Service, São José do Rio Preto, SP, Brazil. dr.joao@terra.com.br
Anais Brasileiros De Dermatologia
|June 25, 2013
Summary
Neurofibromatosis is a genetic disorder affecting multiple body systems, including skin and the nervous system. This review details its historical progression and provides an updated overview of the condition.
Area of Science:
- Genetics
- Neurology
- Dermatology
Background:
- Neurofibromatosis, first described in 1882, is a complex genetic disorder.
- It is characterized by neuroectodermal abnormalities and progressive systemic involvement.
Observation:
- Manifestations vary significantly between individuals.
- Key affected areas include skin, nervous system, bones, and eyes.
Findings:
- This work provides a chronological history of neurofibromatosis research.
- It also offers a comprehensive update on current knowledge of the disease.
Implications:
- Facilitates deeper investigation into neurofibromatosis.
- Aids in understanding the diverse clinical spectrum of the disorder.
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