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Updated: May 10, 2026

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats

Surgical Approach, Challenges, and Resolutions for Uterus Transplantation in Rats

Published on: April 14, 2023

Risks for donors in uterus transplantation.

Iori Kisu¹, Makoto Mihara, Kouji Banno

¹1Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.

Reproductive Sciences (Thousand Oaks, Calif.)

|June 25, 2013

Summary

Uterus transplantation (UTx) offers an alternative for uterine infertility but requires careful consideration of medical, ethical, and social risks for all involved. This review focuses on the burdens and risks for uterus donors.

Keywords:

donor surrogacy uterine infertility uterus transplantation

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Area of Science:

Reproductive Medicine
Transplantation Surgery
Medical Ethics

Background:

Uterus transplantation (UTx) presents a novel option for individuals with absolute uterine infertility, moving from animal studies to human clinical trials.
Existing human UTx procedures necessitate thorough evaluation of associated medical, ethical, and social challenges.
The perspectives of donors, recipients, families, and newborns are crucial for assessing UTx's viability.

Purpose of the Study:

To critically review the burdens and risks associated with uterus transplantation (UTx).
To specifically highlight the challenges and potential negative impacts on uterus donors.
To inform the discussion on the widespread clinical application of UTx.

Main Methods:

Literature review of published studies on uterus transplantation in humans and animals.
Analysis of medical, ethical, and social factors impacting UTx.
Focus on donor-related complications and outcomes.

Main Results:

Uterus transplantation is technically feasible in humans but carries significant risks.
Donors face surgical complications and potential long-term health issues.
Ethical and social considerations for donors, recipients, and offspring require further investigation.

Conclusions:

Uterus transplantation is a complex procedure with substantial risks that need careful management.
The well-being and safety of uterus donors are paramount and require extensive ethical and medical scrutiny.
Further research and societal discussion are essential before widespread clinical adoption of UTx.