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[Basic principles for the development of biomarkers in oncology]
Raquel Seijas1, Jesús Herranz, Nuria Malats
1Grupo de Epidemiología Genética y Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, España.
Archivos Espanoles De Urologia
|June 25, 2013
Summary
Cancer research is shifting towards personalized medicine, using molecular biomarkers to tailor treatments. This review covers biomarker types and development for improved oncology care and reduced adverse events.
Area of Science:
- Oncology and Molecular Biology
- Genetics and Genomics
Context:
- Shift from empiricism to evidence-based oncology.
- Advancements in molecular biology techniques driving personalized medicine.
Purpose:
- Review various types of cancer biomarkers.
- Outline methodological principles for biomarker development and validation.
- Discuss clinical applications of biomarkers in oncology.
Summary:
- Molecular alterations are crucial for tumor development and can be detected as biomarkers.
- Biomarkers aid in cancer risk assessment, diagnosis, prognosis, and therapy response prediction.
- Personalized medicine aims for greater therapeutic efficacy and reduced adverse events through biomarker use.
Impact:
- Facilitates personalized medicine in oncology.
- Enhances therapeutic efficacy and minimizes adverse events.
- Establishes guidelines for biomarker development and clinical integration.
