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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Updated: May 10, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Stem cells in prostate cancer.

Francesca Mateo1, Pedro L Fernandez, Timothy M Thomson

  • 1Laboratory of Cell Signaling and Cancer, Department of Cell Biology, Barcelona Institute for Molecular Biology, CSIC, Barcelona, Spain.

Archivos Espanoles De Urologia
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

Prostate cancer involves a hierarchy of cells, including cancer stem cells (CSCs). These CSCs drive tumor growth and resistance to treatment, making them crucial targets for managing prostate adenocarcinoma.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Prostate Cancer Research

Background:

  • Tumors are complex ecosystems involving neoplastic cells and host interactions.
  • Prostate adenocarcinoma exhibits cellular heterogeneity driven by a cancer stem cell (CSC) hierarchy.
  • CSCs possess self-renewal capacity and drive tumor growth and evolution.

Purpose of the Study:

  • To explore the role of cancer stem cells (CSCs) in prostate adenocarcinoma heterogeneity.
  • To understand the self-renewal and differentiation mechanisms of CSCs.
  • To highlight the significance of CSCs in treatment resistance and disease progression.

Main Methods:

  • Review of existing evidence on prostate cancer stem cells.
  • Analysis of CSC self-renewal and differentiation pathways.
  • Discussion of CSCs' role in androgen-insensitivity and chemotherapy resistance.

Main Results:

  • CSCs are a small subpopulation responsible for tumor growth and heterogeneity.
  • CSC self-renewal is regulated by gene networks and environmental cues.
  • CSCs are implicated in castration-resistant and chemotherapy-insensitive prostate tumors.

Conclusions:

  • Cancer stem cells are critical drivers of prostate cancer progression and treatment resistance.
  • Identifying and quantifying CSCs is vital for effective disease management.
  • Targeting CSCs offers a promising therapeutic strategy for prostate adenocarcinoma.