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Published on: November 9, 2019
Recent advances in the Willgerodt-Kindler reaction
Daniel L Priebbenow1, Carsten Bolm
1Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany. carsten.bolm@oc.rwth-aachen.de.
Recent advancements, including microwave-assisted heating, have revitalized the Willgerodt-Kindler reaction for synthesizing amides, carboxylic acids, and heterocycles, making it more efficient and eco-friendly.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- The Willgerodt-Kindler reaction is an underutilized synthetic organic chemistry process.
- Recent technological advancements offer opportunities to improve its application.
Purpose of the Study:
- To review recent developments in the Willgerodt-Kindler reaction.
- To highlight its utility in synthesizing valuable organic compounds.
Main Methods:
- Literature review of recent Willgerodt-Kindler reaction protocols.
- Focus on methods employing modern techniques like microwave-assisted heating.
Main Results:
- Development of new, high-yielding reaction protocols.
- Demonstration of practical and environmentally friendly synthetic routes.
- Successful synthesis of (thio)amides, carboxylic acids, and heterocycles.
Conclusions:
- The Willgerodt-Kindler reaction is a valuable and increasingly efficient synthetic tool.
- Modern techniques enhance the reaction's practicality and environmental profile.
- Further exploration of this reaction is warranted for diverse synthetic applications.
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