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Updated: May 10, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Interventions for cutaneous Bowen's disease.

Fiona J Bath-Hextall1, Rubeta N Matin, David Wilkinson

  • 1School of Nursing, Faculty of Medicine and Health Sciences, The University of Nottingham, Nottingham, UK. fiona.bath-hextall@nottingham.ac.uk.

The Cochrane Database of Systematic Reviews
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

This review found limited evidence on Bowen's disease treatments, with some studies suggesting methyl aminolevulinate with photodynamic therapy (MAL-PDT) may be effective. More high-quality research is needed to compare treatments and guide clinical decisions.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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11:39

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Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Oncology
  • Evidence-Based Medicine

Background:

  • Bowen's disease is in situ squamous cell carcinoma of the skin, presenting as scaly patches on sun-exposed areas.
  • While generally having an excellent prognosis, it carries a small risk of progressing to invasive squamous cell carcinoma.
  • The comparative effectiveness and side-effect profiles of available treatments for Bowen's disease are not well-established.

Purpose of the Study:

  • To systematically assess the effects of various therapeutic interventions for cutaneous Bowen's disease.
  • To identify the most effective treatment with the fewest side effects.

Main Methods:

  • Comprehensive literature search of multiple databases up to September 2012, including Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, EMBASE, PsycINFO, and LILACS.
  • Inclusion of all randomized controlled trials (RCTs) evaluating interventions for Bowen's disease, prioritizing histologically confirmed cases.
  • Independent study selection and methodological quality assessment by two authors.

Main Results:

  • Methyl aminolevulinate with photodynamic therapy (MAL-PDT) showed significantly greater lesion clearance compared to placebo-PDT and cryotherapy in single studies.
  • No significant difference in clearance was observed between MAL-PDT and 5-fluorouracil (5-FU).
  • 5-aminolevulinic acid with photodynamic therapy (ALA-PDT) demonstrated significantly greater clearance than 5-FU, but recurrence rates at 12 months were not significantly different. Imiquimod showed significantly higher clearance rates than placebo.

Conclusions:

  • High-quality research on Bowen's disease treatments is scarce, limiting definitive conclusions.
  • Limited evidence suggests MAL-PDT may be effective, with potentially favorable cosmetic outcomes, but longer follow-up is needed.
  • Further research is required, especially in immunosuppressed populations, to guide treatment choices based on lesion characteristics and comparative effectiveness.