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Updated: May 10, 2026
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
A new multiresponsive drug delivery system using smart nanogels
Gökçen Birlik Demirel1, Regine von Klitzing
1Department of Chemistry, Faculty of Art and Literature, Gazi University, 06900 Polatli, Ankara, Turkey. gbirlik@gazi.edu.tr
Summary
This study introduces novel multiresponsive nanogels for hydrophobic drug delivery. These P(VCL-co-DMAEMA) nanogels offer controlled release triggered by temperature, pH, and ultrasound.
Area of Science:
- Polymer Science and Engineering
- Materials Science
- Drug Delivery Systems
Background:
- Developing stimuli-responsive materials is crucial for advanced drug delivery.
- Existing systems often lack multi-responsiveness or efficient hydrophobic drug encapsulation.
Purpose of the Study:
- To synthesize and characterize novel temperature- and pH-responsive nanogels.
- To evaluate their potential for multiresponsive drug delivery of hydrophobic drugs.
Main Methods:
- Surfactant-free emulsion polymerization of VCL and DMAEMA monomers.
- Dynamic light scattering for particle size analysis.
- Drug loading and release studies using Rhodamine B (RhB).
Main Results:
- Synthesized P(VCL-co-DMAEMA) nanogels with tunable sizes (81-368 nm).
- Demonstrated re-entrant phase transition behavior with temperature and pH sensitivity (max size at pH 5.0).
- Achieved efficient, ultrasound-enhanced pulsatile release of RhB for long-term and one-shot delivery.
Conclusions:
- P(VCL-co-DMAEMA) nanogels are effective cargo systems for hydrophobic drugs.
- Multiresponsive nanogels offer versatile controlled release capabilities.
- Potential for novel therapeutic applications in drug delivery.
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