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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.

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Related Experiment Video

Updated: May 10, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

GeneMANIA prediction server 2013 update.

Khalid Zuberi1, Max Franz, Harold Rodriguez

  • 1The Donnelly Centre, University of Toronto, Ontario, Canada.

Nucleic Acids Research
|June 25, 2013
PubMed
Summary
This summary is machine-generated.

GeneMANIA is a web tool that helps researchers generate gene function hypotheses and prioritize genes for study. It identifies functionally similar genes using genomics and proteomics data, aiding in biological discovery.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Bioinformatics
  • Systems Biology
  • Genomics

Background:

  • Understanding gene function is crucial for biological research.
  • Analyzing large-scale genomics and proteomics data presents significant challenges.
  • Prioritizing genes for experimental validation requires efficient tools.

Purpose of the Study:

  • To introduce GeneMANIA, a user-friendly web interface for gene function hypothesis generation.
  • To enable the analysis of gene lists and prioritization of genes for functional assays.
  • To facilitate gene function prediction based on interaction networks.

Main Methods:

  • GeneMANIA utilizes a comprehensive collection of genomics and proteomics datasets from public repositories.
  • It employs network analysis to identify functionally similar genes based on interactions.
  • The tool provides weights indicating the predictive value of different data types.

Main Results:

  • GeneMANIA successfully extends query gene lists with functionally related genes.
  • It supports hypothesis generation by highlighting potential gene functions through enriched Gene Ontology categories.
  • The platform supports seven model organisms and allows user-customized data analysis.

Conclusions:

  • GeneMANIA offers a flexible and powerful platform for exploring gene function and biological networks.
  • It aids researchers in prioritizing genes for experimental validation and accelerating biological discovery.
  • The tool's ability to integrate diverse datasets enhances its utility in systems biology research.