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Updated: May 10, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
1-[4-(Di-methyl-amino)-benzyl-idene]-4-o-tolyl-thio-semicarbazide
Rui-Yun Huang1, Qin-Juan Xu, Li-Rong Lin
1Department of Chemistry, Xiamen University, Xiamen 361005, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C17H20N4S, contains two independent mol-ecules, the main difference between them being the dihedral angles between the benzene rings [19.99 (17) and 9.72 (17)°]. The mol-ecules both have a trans conformation about the C=N double bond and intra-molecular C-H⋯S and N-H⋯N hydrogen bonds are observed in both mol-ecules. In the crystal, mol-ecules are linked by weak N-H⋯S hydrogen bonds with graph-set motif R 2 (2)(8). In each mol-ecule, all but one of the N atoms and both the S atoms are involved in hydrogen bonding.
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