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Related Experiment Video

Updated: May 10, 2026

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51

Published on: February 13, 2019

Rad51, friend or foe?

Sue Mei Tan-Wong¹, Nick J Proudfoot

¹is at the Sir William Dunn School of Pathology , University of Oxford , Oxford , United Kingdom sue.wong@path.ox.ac.uk.

|June 25, 2013

Summary

A protein known for DNA repair surprisingly also causes DNA damage. This discovery challenges our understanding of cellular mechanisms and disease development.

Area of Science:

Molecular biology
Genetics
Biochemistry

Background:

The protein is well-established for its crucial role in DNA repair pathways.
Recent findings suggest a dual function for this protein.

Purpose of the Study:

To investigate the paradoxical role of the protein in DNA damage.
To elucidate the mechanisms underlying this dual function.

Main Methods:

Utilized molecular biology techniques.
Employed genetic analysis.
Performed biochemical assays.

Main Results:

The protein actively contributes to DNA damage.
Specific molecular pathways involved in damage induction were identified.

Keywords:

DNA repair Genome Instability R loops RNA-DNA hybrids Rad51 S. cerevisiae

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Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

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Last Updated: May 10, 2026

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51

Published on: February 13, 2019

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Conclusions:

The protein's function extends beyond DNA repair to include DNA damage induction.
This finding has implications for understanding genomic instability and disease.