Secondary generalization of seizures from a cortical penicillin focus following stimulation of the basal forebrain

The basal forebrain has been implicated in the regulation of generalized motor convulsive activity particularly from amygdala kindling. The effect of electrical stimulation of the substantia innominata and ventral pallidal regions of the basal forebrain in rats with acute interictal penicillin foci in the frontal parietal neocortex was determined. Stimulation of this area resulted in generalized cortical EEG synchronization, an inconsistent effect on interictal spike frequency, and generalized seizures that were not prevented by atropine. The results support a role for these basal forebrain structures in the regulation of generalized seizures from a cortical focus mediated primarily through influences on thalamocortical pathways.