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Updated: May 10, 2026
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Highly cross-linked and biocompatible polyphosphazene-coated superparamagnetic Fe3O4 nanoparticles for magnetic
Ying Hu1, Lingjie Meng, Lvye Niu
1School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Abstract:
Highly cross-linked and biocompatible poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) were used to directly coat hydrophilic superparamagnetic Fe3O4 nanoparticles by a facile but effective one-pot polycondensation. The obtained core-shell Fe3O4@PZS nanohybrids were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction spectra. Interesting, the size and T2 relaxivity of Fe3O4@PZS increased with increasing the mass ratio of Fe3O4 to PZS. All these nanohybrids could be internalized by HeLa cells but show negligible cytotoxicity. The PZS layer slowly degraded into less dangerous forms such as 4,4'-sulfonyldiphenol, phosphate and ammonia at neutral or acid atmosphere. Considering their excellent water dispersibility, colloidal and chemical stability, magnetic manipulation, and magnetic resonance imaging (MRI) properties, Fe3O4@PZS nanohybrids have great potential in MRI diagnosis of cancer.
