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Updated: May 10, 2026
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
Cellular responses to hypoxia in the pulmonary circulation
David J Welsh1, Andrew J Peacock
1Scottish Pulmonary Vascular Unit, Regional Heart and Lung Center, Glasgow, United Kingdom.
High Altitude Medicine & Biology
|June 26, 2013
Summary
Hypoxia, a lack of oxygen, causes pulmonary hypertension through vasoconstriction and vascular remodeling. This review explores hypoxia
Area of Science:
- Physiology
- Pathology
- Cardiovascular Research
Background:
- Hypoxia, or reduced oxygen availability, is a significant factor in human health.
- It is a known cause of pulmonary hypertension in conditions like chronic lung disease and high-altitude living.
Purpose of the Study:
- To review the effects of hypoxia on pulmonary vasculature cells.
- To provide insight into the underlying mechanisms of hypoxic pulmonary vascular responses.
Main Methods:
- Literature review of studies on hypoxia and pulmonary vasculature.
- Analysis of cellular responses in the pulmonary artery.
Main Results:
- Hypoxia induces hypoxic pulmonary vasoconstriction (HPV) via smooth muscle cell contraction.
- Hypoxia also leads to pulmonary vascular remodeling (PVR) through cell proliferation.
- The review examines effects on endothelial, smooth muscle, and fibroblast cells.
Conclusions:
- Hypoxia significantly impacts pulmonary artery cells.
- Understanding these cellular mechanisms is crucial for addressing hypoxic pulmonary hypertension.
Related Concept Videos
01:23Hypoxia
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Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
01:21Acute Respiratory Failure-II
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The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:27Oxygen Transport in the Blood
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01:23Physiological Control of Respiration
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01:20Respiration and Gaseous Exchange
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