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Protein kinase C inhibitors: a patent review (2008 - 2009)

M Elizabeth Sobhia1, Baljinder K Grewal, Stanly Paul Ml

  • 1National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmacoinformatics , Sector 67, SAS Nagar (Mohali), Punjab , India mesophia@niper.ac.in.

Expert Opinion on Therapeutic Patents
|June 26, 2013
PubMed
Abstract

Insights

Protein kinase C (PKC) inhibitors are reviewed, highlighting their therapeutic potential for various diseases. Research gaps exist in selectively targeting PKC isoforms and exploring novel inhibitor designs.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Protein kinase C (PKC) is a family of multifunctional enzymes crucial for cell signaling, proliferation, and differentiation.
  • PKC dysregulation is implicated in numerous diseases, including cancer, inflammation, and diabetes.

Purpose of the Study:

  • To review existing protein kinase C (PKC) inhibitors with clinical relevance.
  • To analyze patents filed for PKC inhibitors between 2008 and 2009.

Main Methods:

  • Comprehensive literature and patent survey.
  • Focus on clinically significant PKC inhibitors and recent patent filings.

Main Results:

  • Identified key PKC inhibitors and their associated patents.
  • Highlighted the therapeutic potential of PKCs in various disorders.

Conclusions:

  • PKCs represent promising therapeutic targets for diabetic, oncological, inflammatory, immunological, and dermatological conditions.
  • Challenges remain in selective isoform targeting due to conserved catalytic domains.
  • Further research is needed on bisubstrate inhibitors and exploring chemical space for PKCs.

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