Related Experiment Video

Updated: May 10, 2026

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Oxidative and antioxidative status of children with acute bronchiolitis

Rusen Dundaroz1, Ufuk Erenberk, Ozden Turel

  • 1Department of Pediatrics, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey.

Jornal De Pediatria
|June 26, 2013
PubMed

Insights

Oxidative stress is elevated in children with acute bronchiolitis, with higher oxidant and lower antioxidant levels observed. This imbalance, particularly in moderate cases, suggests a role in disease development.

Area of Science:

  • Pediatric Medicine
  • Biochemistry
  • Respiratory Diseases

Background:

  • Oxidative stress is implicated in the pathogenesis of acute and chronic lung inflammatory diseases.
  • Understanding the oxidant/antioxidant balance is crucial for managing pediatric respiratory conditions.

Purpose of the Study:

  • To evaluate the oxidant/antioxidant status in children diagnosed with acute bronchiolitis.
  • To compare plasma total antioxidant capacity, total oxidant status, and oxidative stress index between patients and healthy controls.

Main Methods:

  • A comparative study involving 31 children with acute bronchiolitis and 39 age-matched healthy controls.
  • Assessment of plasma total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI).
  • Classification of bronchiolitis patients into mild and moderate severity groups.

Main Results:

  • Children with acute bronchiolitis exhibited significantly higher TOS and lower TAC compared to controls.
  • Moderate bronchiolitis cases showed elevated TOS and OSI levels compared to mild cases and controls.
  • A negative correlation was found between oxygen saturation and TOS in bronchiolitis patients.

Conclusions:

  • The study demonstrates a disrupted oxidant-antioxidant system balance in children with moderate acute bronchiolitis.
  • Oxidative stress is identified as a potential contributing factor in the pathogenesis of acute bronchiolitis.
  • Findings highlight the importance of addressing oxidative stress in the management of pediatric lung inflammation.
Abstract

Keywords:
BronchiolitisBronquioliteEstresseInfantNeonatoOxidanteOxidativeStress

More Related Videos

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro03:35

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro

Published on: June 28, 2024

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...