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Related Experiment Video

Updated: May 10, 2026

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Polar body biopsy.

Markus Montag1, Maria Köster, Thomas Strowitzki

  • 1Department of Gynecologic Endocrinology and Fertility Disorders, Ruprecht-Karls University Heidelberg, Heidelberg, Germany. mmontag@ilabcomm.com

Fertility and Sterility
|June 26, 2013
PubMed
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Polar body biopsy with array comparative genomic hybridization detects maternal chromosomal issues. This method offers an alternative to blastomere and trophectoderm biopsy, despite some limitations.

Area of Science:

  • Reproductive biology
  • Genetics
  • Embryology

Background:

  • Preimplantation genetic testing (PGT) is crucial for identifying chromosomal abnormalities in embryos.
  • Traditional biopsy methods like blastomere or trophectoderm biopsy have associated risks and limitations.
  • Maternal chromosomal factors can significantly impact reproductive outcomes.

Purpose of the Study:

  • To evaluate the efficacy of polar body biopsy in conjunction with array comparative genomic hybridization (aCGH) for detecting maternal chromosomal aberrations.
  • To assess the potential of polar body biopsy as an alternative PGT method.

Main Methods:

  • Polar bodies were collected following oocyte retrieval.
  • Array comparative genomic hybridization (aCGH) was performed on the biopsied polar bodies.
Keywords:
PGSPolar body biopsyaneuploidyarray-CGHoocyte

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Last Updated: May 10, 2026

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

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  • Analysis focused on identifying aneuploidies and other chromosomal imbalances originating from the mother.

    • Main Results:

    • Polar body biopsy combined with aCGH successfully identified maternal chromosomal aberrations.
    • The technique demonstrated potential in detecting specific types of chromosomal errors.

    Conclusions:

    • Polar body biopsy coupled with aCGH is a viable method for detecting maternal chromosomal abnormalities.
    • This approach presents a valuable alternative to conventional blastomere and trophectoderm biopsy techniques in preimplantation genetic testing.