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Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Related Experiment Video

Updated: May 10, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

The blue globular pattern in dermoscopy.

V Roberti¹, V Devirgiliis, M Curzio

¹Department of Dermatology, University of Rome Sapienza, Rome, Italy.

Dermatology (Basel, Switzerland)

|June 26, 2013

Summary

This summary is machine-generated.

Seborrheic keratosis (SK) can mimic melanocytic lesions. A blue globular pattern on dermoscopy, though uncommon, aids in diagnosing SK when typical features are absent.

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Area of Science:

Dermatology
Dermoscopy
Histopathology

Background:

Seborrheic keratosis (SK) is a common benign skin tumor.
Clinical diagnosis of SK can be challenging due to resemblance to melanocytic lesions.
Dermoscopy is crucial for accurate SK diagnosis, revealing features like milia-like cysts and comedo-like openings.

Purpose of the Study:

To describe a case series of SKs exhibiting a blue globular pattern.
To highlight the diagnostic utility of this pattern in simulating melanocytic lesions.

Main Methods:

Retrospective evaluation of 224 SK cases.
Analysis of dermoscopic findings from the Dermatoscopy Unit, University of Rome.
Histopathologic examination for confirmation.

Main Results:

Five SKs presented with a blue globular pattern.
These lesions lacked typical SK dermoscopic features.
Histopathology confirmed acanthotic SK.

Conclusions:

The blue globular pattern is a useful dermoscopic indicator for SK.
This pattern aids in diagnosing SK, particularly when characteristic features are absent.