Related Experiment Video
Updated: May 10, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
Rapid progression and brain atrophy in anti-AMPA receptor encephalitis
Yi-Chia Wei1, Chi-Hung Liu, Jainn-Jim Lin
1Department of Neurology, Keelung Medical Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
Abstract:
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is an anti-neuronal surface antigen autoimmune encephalitis that is rarely reported. Our study evaluated the first known patient who developed anti-AMPA receptor encephalitis during pregnancy. Initial brain MRI revealed bilateral limbic encephalitis. However, rapid brain atrophy on MRI with extensive hypometabolism of cerebral cortices, caudate nuclei and brain stem hypoperfusion on (18)F-FDG PET developed when clinically progressed. IgG index of serial CSF studies reflected the clinical improvements after plasmapheresis and plasma exchange. The clinical spectrum of anti-AMPA receptor encephalitis may be expanded from limited limbic involvement to extended central nervous system.
More Related Videos
Related Concept Videos
Encephalitis ll: Pathophysiology
Encephalitis l: Introduction
Arboviral Encephalitis
Alzheimer Disease ll: Pathophysiology
Brain Abscess l: Introduction
Hepatic Encephalopathy

