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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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Related Experiment Video

Updated: May 10, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Published on: September 30, 2021

Hepatobiliary malignancies: lessons from Asia.

Tiffany C L Wong1, Ronnie T P Poon

  • 1Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Digestive Diseases (Basel, Switzerland)
|June 26, 2013
PubMed
Summary
This summary is machine-generated.

Asian centers offer advanced treatments for liver cancer (HCC) and bile duct cancer (CCA), differing from Western approaches. Collaboration is key to optimizing strategies for these hepatobiliary malignancies.

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Last Updated: May 10, 2026

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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

Area of Science:

  • Hepatobiliary Malignancies
  • Surgical Oncology
  • Gastroenterology

Background:

  • Higher incidence of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) in Asia compared to the West.
  • Hepatitis B is the primary HCC risk factor in Asia, unlike hepatitis C in Western populations.
  • Western Barcelona Clinic for Liver Cancer (BCLC) staging is often deemed too conservative by Asian centers.

Purpose of the Study:

  • To highlight the significant contributions of Asian centers to managing HCC and CCA.
  • To compare and contrast Eastern and Western treatment strategies for hepatobiliary malignancies.
  • To advocate for international collaboration in advancing treatment protocols.

Main Methods:

  • Review of current management practices in Asian and Western centers for HCC and CCA.
  • Analysis of differences in surgical approaches, including resection and transplantation criteria.
  • Examination of pioneering techniques such as living donor liver transplantation in Asia.

Main Results:

  • Asian centers employ more extended criteria for liver resection and transplantation in HCC.
  • Living donor liver transplantation is crucial in Asia for HCC management due to graft scarcity.
  • Asian centers adopt aggressive surgical strategies for CCA, including radical lymphadenectomy and combined vascular resections.

Conclusions:

  • Asian centers provide innovative and aggressive management for HCC and CCA.
  • Divergent approaches in Asia and the West necessitate further collaborative research.
  • Optimizing treatment strategies for hepatobiliary malignancies requires integrating Eastern and Western expertise.