Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
06:38

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

Bioactive phenylpropanoid glycosides from Tabebuia avellanedae.

Maorong Suo1, Tomihisa Ohta, Fumihide Takano

  • 1Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. suomaorong@163.com

Molecules (Basel, Switzerland)
|June 26, 2013
PubMed
Summary

Researchers identified novel phenylpropanoid glycosides from Tabebuia avellanedae. These compounds demonstrated significant antioxidant activity, with one showing exceptional potency, and also moderate inhibition of cytochrome P450 3A4 (CYP3A4).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug repurposing in traditional Chinese medicine: from empirical wisdom to modern therapeutic strategies.

Frontiers in pharmacology·2025
Same author

Sphingolipid-Enriched Porcine Placental Extract Promotes the Expression of Structural Genes and Desquamation Enzyme Genes in Cultured Human Keratinocytes.

Biological & pharmaceutical bulletin·2024
Same author

Isolation and identification of novel selective antitumor constituents, sidrin and sidroside, from <i>Zizyphus spina-christi</i>.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society·2023
Same author

Phytochemical and in silico studies for potential constituents from <i>Centaurium spicatum</i> as candidates against the SARS-CoV-2 main protease and RNA-dependent RNA polymerase.

Natural product research·2021
Same author

Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.

Neuroscience letters·2019
Same author

Anti-inflammatory Effect of the Water-Soluble Portion of Porcine Placental Extract in Lipopolysaccharide-Stimulated RAW264.7 Murine Macrophage Cells.

Biological & pharmaceutical bulletin·2018

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Tabebuia avellanedae is a plant species known for its potential medicinal properties.
  • Phenylpropanoid glycosides are a class of natural compounds with diverse biological activities.
  • Understanding the chemical constituents and bioactivities of medicinal plants is crucial for drug discovery.

Purpose of the Study:

  • To isolate and identify novel and known phenylpropanoid glycosides from the water extract of Tabebuia avellanedae.
  • To evaluate the antioxidant potential of the isolated compounds using the DPPH assay.
  • To assess the inhibitory effects of the compounds on the cytochrome P450 3A4 (CYP3A4) enzyme.

Main Methods:

  • Water extraction of Tabebuia avellanedae.

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
06:38

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through spectroscopic analysis (NMR, MS) and chemical methods.
  • Antioxidant activity assessment via DPPH radical scavenging assay.
  • In vitro inhibition assay for cytochrome P450 3A4 (CYP3A4) enzyme activity.

    • Main Results:

    • Three novel phenylpropanoid glycosides (2, 5, 6) and three known ones (1, 3, 4) were successfully isolated and identified.
    • All isolated compounds exhibited strong antioxidant activity.
    • Compound 5 displayed the highest antioxidant activity with an IC50 value of 0.12 µM.
    • All compounds demonstrated moderate inhibitory effects on the cytochrome CYP3A4 enzyme.

    Conclusions:

    • The water extract of Tabebuia avellanedae is a rich source of bioactive phenylpropanoid glycosides.
    • The identified compounds possess significant antioxidant properties, with potential therapeutic applications.
    • The moderate CYP3A4 inhibition suggests potential interactions with drug metabolism pathways, warranting further investigation.