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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:

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T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis
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Published on: July 31, 2010

Multiple mass analysis using an ion trap array (ITA) mass analyzer.

Xiao Yu1, Yanqiu Chu, Xing Ling

  • 1Department of Chemistry and Laser Chemistry Institute, Fudan University, Shanghai, China.

Journal of the American Society for Mass Spectrometry
|June 26, 2013
PubMed
Summary
This summary is machine-generated.

A new ion trap array (ITA) enables simultaneous analysis of multiple samples using six parallel channels. This mass analyzer achieves independent mass spectra and demonstrates key ion trap functions for enhanced throughput.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry Instrumentation

Background:

  • Simultaneous analysis of multiple samples is crucial for high-throughput screening.
  • Existing mass spectrometry systems often lack parallel processing capabilities for multiple samples.

Purpose of the Study:

  • To investigate a novel ion trap array (ITA) mass analyzer designed for simultaneous multi-sample analysis.
  • To evaluate the performance and capabilities of the ITA system in parallel mass spectrometry.

Main Methods:

  • Fabrication of a six-channel ion trap array using stainless steel electrodes and zirconia ceramic substrates.
  • Simulation of electric field distribution within the ITA channels.
  • Testing the ITA system with a two-channel electrospray ionization source, multichannel ion guide, and detectors.

Main Results:

  • Successful simultaneous analysis of two different samples using adjacent ITA channels, yielding independent mass spectra.
  • Demonstration of essential ion trap functions including mass resolution, mass-selected ion isolation, and collision-induced dissociation (CID).

Conclusions:

  • The novel ion trap array (ITA) is well-suited for multiple simultaneous mass analyses.
  • The design leverages ceramic rigidity and surface patterning for high-precision instrumentation.
  • The ITA system offers a promising solution for increasing analytical throughput in mass spectrometry.