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Disease patterns of juvenile dermatomyositis from Western India

Pranav R Chickermane1, Deepali Mankad, Raju P Khubchandani

  • 1Department of Pediatrics, Jaslok Hospital and Research Centre, Dr G Deshmukh Marg, Mumbai, India. Correspondence to: Dr Raju P Khubchandani, 31, Kailas Darshan, Near Kennedy Bridge, Nana Chowk, Mumbai 400 007, India. rajukhubchandani@yahoo.co.in.

Indian Pediatrics
|June 27, 2013
PubMed

Insights

This study assessed juvenile dermatomyositis (JDM) in 22 Indian children, finding typical symptoms and elevated muscle enzymes. Most patients experienced a favorable outcome with no mortality, differing from Western studies.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Dermatology

Background:

  • Juvenile dermatomyositis (JDM) is a rare autoimmune disease affecting children.
  • Understanding JDM's clinical course and outcomes in diverse populations is crucial.

Purpose of the Study:

  • To retrospectively analyze the clinical features, complications, treatments, and outcomes of JDM in an Indian cohort.
  • To compare findings with existing Western literature.

Main Methods:

  • Retrospective chart review of 22 children diagnosed with JDM between 1997 and 2012.
  • Assessment of clinical presentation, laboratory data, complications, treatment, and patient outcomes.

Main Results:

  • All patients presented with characteristic rash and muscle weakness; all had elevated serum muscle enzymes.
  • Common complications included cutaneous ulcers (27.27%), dysphagia (22.72%), and calcinosis (18.18%).
  • A monocyclic disease course was observed in 72.7% of patients, with no mortality or significant cardiopulmonary complications.

Conclusions:

  • The study highlights distinct clinical characteristics and a generally favorable prognosis for JDM in this Indian cohort.
  • Findings suggest potential differences in JDM presentation and outcome compared to Western populations, warranting further investigation.

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