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Disseminated histoplasmosis with oral and cutaneous manifestations

S Vidyanath1, Pm Shameena, S Sudha

  • 1Department of Oral and Maxillofacial Pathology, Government Dental College, Calicut, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|June 27, 2013
PubMed

Insights

Disseminated histoplasmosis, a fungal infection, can affect anyone, not just those with weakened immune systems. This case highlights a rare occurrence in an HIV-negative individual, emphasizing the need for broader diagnostic considerations.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum.
  • It is often opportunistic, particularly in human immunodeficiency virus (HIV)-positive individuals.
  • Cases in India are historically rare, with fewer than 50 reported.

Observation:

  • A case of disseminated histoplasmosis was observed.
  • The patient was seronegative for HIV.
  • The infection presented with oral and cutaneous manifestations.

Findings:

  • This report details a rare instance of disseminated histoplasmosis in an immunocompetent patient.
  • The oral and cutaneous involvement signifies extensive disease spread.
  • The case challenges the typical association of severe histoplasmosis with immunosuppression.

Implications:

  • Highlights the potential for histoplasmosis in HIV-negative individuals, even in non-endemic regions.
  • Suggests broader diagnostic awareness for disseminated fungal infections beyond immunocompromised populations.
  • Underscores the importance of recognizing diverse clinical presentations of Histoplasma capsulatum infections.
Keywords:
Disseminatedhistoplasmosishuman immunodeficiency virus

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