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Skin decontamination cream for radiological contaminants: Formulation development and evaluation
Abdul Wadood Khan1, Sabna Kotta, Sudha Rana
1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
International Journal of Pharmaceutical Investigation
|June 27, 2013
Summary
A new radiation decontamination cream effectively removed 42% of technetium-99m radiocontaminants from skin within 30 minutes. This self-usable formulation showed no signs of skin irritation, offering a promising solution for accidental radioactive exposure.
Area of Science:
- Radiopharmaceutical Sciences
- Dermatology
- Nuclear Medicine
Background:
- Increased use of radioactive materials in medicine, research, and industry heightens the risk of accidental exposure.
- Potential intentional misuse of radioisotopes necessitates immediate self-usable decontamination solutions.
- Development of effective decontamination formulations is crucial for public safety.
Purpose of the Study:
- To optimize and develop a self-usable radiation decontamination cream.
- To evaluate the efficacy and safety of the developed cream for skin decontamination.
Main Methods:
- Formulation optimization and characterization of pharmaceutical parameters.
- Evaluation of decontamination efficacy using technetium-99m sodium pertechnetate as a radiocontaminant.
- Skin decontamination assessment via static counts recorded with single photon emission computed tomography and skin irritancy tests.
Main Results:
- The cream achieved a decontamination efficacy of 42% ± 3% within 0-0.5 hours post-exposure.
- Primary skin irritancy tests were satisfactory, with no observed erythema or edema after two weeks.
Conclusions:
- The developed cream formulation demonstrates significant potential for effective radiological decontamination.
- EDTA (ethylenediaminetetraacetic acid) proved effective in removing radiological contaminants from the skin.
