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Related Experiment Video

Updated: May 10, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Immunoparalysis in sepsis.

R L J Zwinkels¹, L Dawson

¹Department of Intensive Care, Reinier de Graaf Gasthuis, Delft, The Netherlands. r.zwinkels@rdgg.nl

The Netherlands Journal of Medicine

|June 27, 2013

Summary

This summary is machine-generated.

Autopsy revealed unsuspected aspergillosis in two sepsis patients, highlighting a critical diagnostic gap. This finding underscores the risk of opportunistic infections in septic patients experiencing immunoparalysis.

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A Data-Driven Approach to Quantifying Immune States in Sepsis

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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Published on: February 7, 2025

Area of Science:

Medicine
Pathology
Infectious Diseases

Background:

Therapeutic advancements continue, yet mortality persists due to treatment limitations.
Autopsy studies are crucial for elucidating pathophysiology in cases lacking conclusive diagnoses.
Sepsis can lead to a state of immunoparalysis, increasing susceptibility to opportunistic infections.

Observation:

Two patients with prolonged sepsis expired.
Autopsies revealed the unsuspected presence of aspergillosis in both cases.

Findings:

Aspergillosis was an unexpected finding in patients with sepsis.
The literature supports that septic patients are prone to opportunistic infections due to apoptosis and immune interactions, termed immunoparalysis.

Implications:

Autopsy findings can refine our understanding of sepsis-associated complications.
This highlights the importance of considering opportunistic infections like aspergillosis in sepsis management.
Improved diagnostic strategies are needed for identifying fungal infections in immunocompromised septic patients.