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Related Experiment Video

Updated: May 10, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Biopsies: next-generation biospecimens for tailoring therapy.

Mark Basik¹, Adriana Aguilar-Mahecha, Caroline Rousseau

¹Department of Surgery, Jewish General Hospital, McGill University, 3755 Côte Sainte Catherine Road, Montreal, QC H3T 1E2, Canada.

Nature Reviews. Clinical Oncology

|June 27, 2013

Summary

This summary is machine-generated.

Next-generation biobanking requires high-quality tumour biospecimens for advanced research. Collecting these samples presents significant ethical, logistical, and scientific challenges for accurate molecular analysis.

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Last Updated: May 10, 2026

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Area of Science:

Oncology
Biobanking
Molecular Biology

Background:

Existing tumour biobanks primarily contain primary surgical specimens.
Understanding tumour biology requires diverse biospecimens reflecting disease evolution and patient context.
Next-generation 'omics' technologies demand high-quality, representative samples for accurate results.

Purpose of the Study:

To review current practices for procuring and processing next-generation biospecimens.
To highlight the challenges and opportunities in next-generation biobanking.
To discuss the multidisciplinary team requirements for advanced biobanking.

Main Methods:

Review of existing procedures for sample procurement and processing.
Identification of challenges in collecting next-generation biospecimens.
Discussion of organizational and team requirements.

Main Results:

Next-generation biobanking necessitates serial tumour and blood sample collection at defined disease points.
Sample representativeness, viability, quantity, and quality are critical for molecular applications.
Ethical, logistical, scientific, informational, and financial challenges must be addressed.

Conclusions:

Next-generation biobanking is essential for advancing tumour biology insights and personalized medicine.
Overcoming collection and processing challenges is key to maximizing the utility of biospecimens.
A multidisciplinary approach is vital for successful next-generation biobanking initiatives.