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Multicentric plasma cell type of castleman disease in a child: difficulty in diagnosis and treatment
Tuba H Karapinar1, Özlem Tüfekçi, Salih Gözmen
1Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
Insights
Multicentric Castleman disease (CD) is rare in children. This case highlights diagnostic and treatment challenges for the plasma cell variant in a pediatric patient.
Area of Science:
- Pediatric Hematology-Oncology
- Rare Diseases
- Immunology
Background:
- Multicentric Castleman disease (CD), particularly the plasma cell variant, is infrequently documented, especially in pediatric populations.
- Optimal therapeutic strategies for pediatric multicentric CD remain undefined.
Observation:
- A 7-year-old boy presented with cervical lymphadenopathies, indicative of Castleman disease.
- The patient exhibited autoimmune hemolytic anemia, bone marrow insufficiency, and multi-organ involvement including pulmonary, renal, hepatic, and gastrointestinal systems.
Findings:
- The case underscores the diagnostic complexities associated with multicentric plasma cell variant Castleman disease in a child.
- Management of this rare condition presents significant therapeutic hurdles.
Implications:
- This report contributes to the limited literature on pediatric multicentric plasma cell variant CD.
- It emphasizes the need for further research into effective diagnostic and treatment protocols for this rare pediatric condition.
Abstract:
Multicentric plasma cell variant of Castleman disease (CD) has rarely been reported and the optimal therapeutic approach is unknown, especially in childhood. In this case report, we discuss the case of a 7-year-old boy with multicentric plasma cell variant of CD, who presented with cervical lymphadenopathies, autoimmune hemolytic anemia, bone marrow insufficiency, pulmonary, renal, hepatic, and gastrointestinal involvement, emphasizing the difficulty in diagnosis and treatment approach.
