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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: May 10, 2026

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain
25:12

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

Published on: July 29, 2007

Stress and stem cells.

John Tower1

  • 1Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA, USA. jtower@usc.edu

Wiley Interdisciplinary Reviews. Developmental Biology
|June 27, 2013
PubMed
Summary
This summary is machine-generated.

Stem cells are regulated by various stresses, which also influence their division and differentiation. Stress responses like apoptosis and senescence protect against cancer, while aging poses cumulative risks to stem cell function.

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Stromal Cell Isolation From Hematopoietic Organs
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Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain
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Published on: July 29, 2007

Stromal Cell Isolation From Hematopoietic Organs
05:27

Stromal Cell Isolation From Hematopoietic Organs

Published on: January 26, 2024

Area of Science:

  • Stem cell biology
  • Stress response mechanisms
  • Aging research

Background:

  • Stem cells possess unique properties making them susceptible to and regulated by stress.
  • Stem cell division is critical for tissue repair and normal turnover, responding to diverse signals.
  • Stress-response pathways are conserved and play key roles in stem cell self-renewal and differentiation.

Purpose of the Study:

  • To explore the intricate relationship between various stresses and stem cell behavior.
  • To elucidate the role of stress in regulating stem cell division, self-renewal, and differentiation.
  • To understand how stress responses contribute to maintaining stem cell function and preventing transformation.

Main Methods:

  • Review of conserved pathways regulating stem cell self-renewal and differentiation.
  • Analysis of stress-response pathways including oxidative stress, mechanical stress, and signaling molecules.
  • Examination of mechanisms like apoptosis, senescence, quiescence, and niche regulation.
  • Investigation of aging-related cumulative effects on stem cells and their niches.

Main Results:

  • Stem cell division is modulated by signals such as oxidative stress, mechanical stress, growth factors, and cytokines.
  • Conserved stress-response pathways are integral to stem cell self-renewal and differentiation.
  • Antitumor mechanisms in stem cells include apoptosis and senescence, counteracting transformation risk.
  • Quiescence and a hypoxic niche, regulated by CDK inhibitors and FOXO transcription factor, reduce stress for stem cell maintenance.
  • Aging imposes cumulative stress on stem cells, leading to epigenetic dysregulation, mutations, and telomere erosion, and impairs niche function.

Conclusions:

  • Stem cells are highly sensitive to and regulated by a multitude of stresses.
  • Stress responses are fundamental to stem cell maintenance, function, and protection against cancer.
  • Aging represents a significant stressor that cumulatively impacts stem cell integrity and function over time.
  • Understanding these stress-stem cell interactions is crucial for regenerative medicine and aging research.