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Acute renal failure in sickle cell anemia.
The International Journal of Artificial Organs
|June 1, 1990
Summary
Acute renal failure (ARF) affects over 10% of hospitalized sickle cell anemia (SCA) patients, often linked to infection and dehydration. Most patients recover renal function, with some requiring dialysis.
Area of Science:
- Nephrology
- Hematology
- Internal Medicine
Background:
- Sickle cell anemia (SCA) is a genetic blood disorder associated with various complications.
- Acute renal failure (ARF) is a serious condition that can occur in hospitalized patients.
- The incidence and risk factors for ARF in SCA patients require further investigation.
Purpose of the Study:
- To determine the prevalence of ARF in hospitalized patients with SCA.
- To identify risk factors and common causes of ARF in this patient population.
- To describe the outcomes and management of ARF in SCA patients.
Main Methods:
- A case-control study was conducted on patients hospitalized with SCA.
- ARF was defined as a minimum doubling of serum creatinine levels.
- Patient records were analyzed for demographic, clinical, and laboratory data.
Main Results:
- 10.3% of eligible SCA patients (12 out of 116) were diagnosed with ARF.
- ARF patients had higher rates of infection and lower hemoglobin levels.
- Volume depletion was the most frequent identifiable cause of ARF.
Conclusions:
- ARF is a significant complication in hospitalized SCA patients.
- Infection and volume depletion are key factors contributing to ARF in SCA.
- Most ARF patients in this cohort survived and regained renal function, with some needing dialysis.