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Updated: May 10, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases
Marta Ferran1, Ester R Romeu, Catalina Rincón
1Department of Dermatology, Hospital del Mar, Research Group in Inflammatory Dermatologic Diseases, IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.
Abstract:
T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases.
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