Nodular mesangial glomerulosclerosis in patients without manifest diabetes mellitus

Nodular mesangial glomerulosclerosis is considered to be the specific renal lesion of diabetes mellitus, and typical histological lesions in non-diabetic patients have been reported only occasionally. A similar lesion has recently been described in patients suffering from light chain disease. We report on two patients without manifest diabetes and without light chain disease, showing progressive impairment of renal function and typical nodular mesangial glomerulosclerosis.