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Updated: May 10, 2026

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
Published on: January 20, 2010
Tracheal pseudo-tumor caused by herpes simplex virus
Stamatis Katsenos1, Dimitrios Sampaziotis, Stavros Archondakis
1Department of Pneumonology, General Army Hospital of Athens, 158 Mesogion & Katehaki Avenue, 115 25 Athens, Greece. skatsenos@yahoo.gr.
Background:
Herpes simplex virus (HSV) has been shown to cause respiratory tract infections mostly in severely immunocompromised patients. Endobronchial tumor-like lesions have been described very rarely as HSV pulmonary manifestations in critically ill patients or in immunosuppressed individuals.
Case Presentation:
This case study describes a 75-yr-old male who presented with persistent hoarseness. Fiberoptic bronchoscopy showed marked mucosal thickening protruding in mid and distal trachea causing stenosis. Biopsy specimens demonstrated cytopathological changes consistent with HSV type 1 and 2 infection.
Conclusions:
To the best of the authors' knowledge, this is the first reported case of HSV presenting as an endotracheal tumor in an immunocompetent person.
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