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Mesotherapy for local fat reduction.

S Jayasinghe1, T Guillot, L Bissoon

  • 1Rollins School of Public Health, Atlanta, GA, USA.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|June 27, 2013
PubMed
Summary
This summary is machine-generated.

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Mesotherapy for cosmetic fat reduction involves injecting substances into subcutaneous tissue. While popular, its efficacy and safety for fat loss require further FDA-approved research due to inconsistent results and infection risks.

Area of Science:

  • Aesthetic Medicine
  • Dermatology
  • Cosmetic Procedures

Background:

  • Mesotherapy, originating in the 1950s, is utilized in the US primarily for cosmetic fat reduction.
  • This review focuses on mesotherapy applications for local fat reduction, examining its history and physiological basis.

Purpose of the Study:

  • To review existing literature on mesotherapy for local fat reduction.
  • To analyze the history, mechanisms, and safety concerns of different mesotherapy techniques.

Main Methods:

  • Systematic review of manuscripts indexed in PubMed/MEDLINE under the keyword 'mesotherapy'.
  • Analysis of historical development, physiological principles of fat distribution, and mechanisms of lipolytic agents.

Main Results:

Keywords:
Cosmeticfat necrosislipolysis

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  • Mesotherapy categorizes into lipolytic (non-destructive, requiring frequent treatments) and ablative (cell-destroying, causing inflammation/scarring).
  • Local anesthetics in solutions may inhibit lipolysis; infection risk is significant with poor sterile technique.
  • Studies are limited by small sample sizes and lack of standardization.

Conclusions:

  • Current cosmetic mesotherapy practices for fat reduction have safety concerns and variable efficacy.
  • Further research is needed to establish Food and Drug Administration (FDA) indications, moving beyond off-label use.