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Updated: May 10, 2026

A Modified Simple Method for Induction of Myocardial Infarction in Mice

A Modified Simple Method for Induction of Myocardial Infarction in Mice

Published on: December 3, 2021

Binge drinking-induced subtle myocardial injury.

Napoleon Waszkiewicz¹, Agata Szulc, Krzysztof Zwierz

¹Department of Psychiatry, Medical University of Białystok, Choroszcz, Poland. napoleonwas@yahoo.com

Alcoholism, Clinical and Experimental Research

|June 27, 2013

Summary

Binge drinking, or acute alcohol abuse, can cause subtle heart damage and rhythm abnormalities. Frequent heavy drinking events are linked to adverse cardiovascular effects, unlike moderate alcohol intake.

Keywords:

binge drinking myocardial injury

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Area of Science:

Cardiology
Toxicology
Biochemistry

Background:

Chronic alcohol intoxication's effects on myocardial injury are well-studied.
Acute alcohol (binge drinking)-induced cardiotoxicity receives less attention despite its prevalence.
Binge drinking is more common than alcohol dependence.

Purpose of the Study:

To review the cardiovascular effects of acute alcohol consumption (binge drinking).
To highlight the "holiday heart" syndrome associated with binge drinking.
To contrast the effects of acute versus chronic alcohol exposure on the heart.

Main Methods:

Literature search on alcohol's effects on the heart.
Brief presentation of binge drinking-induced "holiday heart" effects.
Synthesis of findings from existing studies.

Main Results:

Binge drinking shows transient myocardial changes via cardiac magnetic resonance.
Elevated serological markers indicate myocardial injury and inflammation.
Abnormal cardiac rhythms, metabolic changes, and coronary vasoconstriction are observed.
Changes in blood pressure, heart rate, and thrombosis/fibrinolysis processes occur.

Conclusions:

Acute low alcohol exposure may benefit myocardial function.
Frequent heavy acute drinking events are associated with adverse cardiovascular outcomes.
Binge drinking poses significant risks to heart health.