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Examination of disruptive behavior outcomes and moderation in a randomized psychotherapy trial for mood disorders
Khrista Boylan1, Heather A Macpherson, Mary A Fristad
1Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, ON, Canada. boylank@mcmaster.ca
Insights
Multifamily psychoeducational psychotherapy (MF-PEP) helps children with mood disorders. This treatment also shows benefits for disruptive behaviors, without worsening mood symptoms, making it a valuable early intervention.
Area of Science:
- Child and Adolescent Psychiatry
- Behavioral Psychology
- Clinical Psychology
Background:
- Multifamily psychoeducational psychotherapy (MF-PEP) is an established treatment for pediatric mood disorders.
- High comorbidity exists between mood disorders and disruptive behaviors in children.
- Understanding the impact of disruptive behaviors on treatment outcomes is crucial.
Purpose of the Study:
- To investigate the association between disruptive behaviors and impairment in children with mood disorders.
- To evaluate the effect of MF-PEP on disruptive behaviors in this population.
- To determine if disruptive behaviors influence the treatment response of mood symptoms.
Main Methods:
- Secondary analysis of a randomized controlled trial comparing MF-PEP to a waitlist control.
- Included 165 children aged 8-11 with mood disorders and their parents.
- Participants received treatment as usual alongside the trial interventions.
Main Results:
- Greater disruptive behaviors correlated with increased mood symptom severity and impairment.
- MF-PEP showed significant effect sizes for reducing symptoms of attention-deficit/hyperactivity disorder and oppositional defiant disorder.
- Baseline disruptive behavior severity did not impede mood symptom improvement with MF-PEP.
Conclusions:
- MF-PEP effectively treats mood disorders in children and offers benefits for comorbid disruptive behaviors.
- The findings support MF-PEP as an early intervention for children with combined mood and disruptive behavior disorders.
- Further research on treatment sequencing for these complex cases is warranted.
Objective:
Multifamily psychoeducational psychotherapy (MF-PEP) is an efficacious treatment for children with mood disorders. Given the comorbidity between disruptive behaviors and mood disorders, this study examined associations between disruptive behaviors and impairment, impact of MF-PEP on disruptive behaviors, and whether disruptive behaviors affected treatment response of mood symptoms.
Method:
Secondary analyses examined a randomized controlled trial of MF-PEP versus waitlist control (N = 165 children 8-11 years old with mood disorders and their parents). Comorbid behavioral diagnoses occurred in 97% of children. All participants continued treatment as usual.
Results:
Greater degree of disruptive behaviors was associated with worse mood symptoms and impairment. Between-group analyses examining outcome of disruptive behaviors were nonsignificant. Within-group analyses and between-group effect sizes suggested that MF-PEP was associated with decreases in attention-deficit/hyperactivity disorder (d = 0.39), oppositional defiant disorder (d = 0.30), and overall disruptive behavior symptoms (d = 0.30), but not conduct disorder symptoms. Baseline severity of disruptive behaviors did not affect treatment response of mood symptoms to MF-PEP.
Conclusions:
MF-PEP is an effective intervention for children with mood disorders and provides some benefit for disruptive behaviors. Given that disruptive behavior severity does not affect children's ability to experience improved mood symptoms, MF-PEP may be an important early intervention for children with comorbid mood and disruptive behavior disorders. Subsequent intervention targeting behavioral symptoms after improvement in mood may be beneficial. Studies examining treatment sequencing for children with comorbid mood and disruptive behavior disorders are needed. Clinical trial registration information-Family psychoeducation for children with mood disorders; http://clinicaltrials.gov; NCT00050557.
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