Related Experiment Video
Updated: May 10, 2026

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
Published on: February 10, 2023
Blood pressure control among stroke patients in Thailand--the i-STROKE study
Samart Nidhinandana1, Disya Ratanakorn2, Nijasri Charnnarong3
1Division of Neurology, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
Insights
Hypertension management in Thai stroke patients shows suboptimal blood pressure control, with less than half achieving targets. Inadequate antihypertensive use and poor patient awareness contribute to uncontrolled blood pressure in stroke survivors.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Public Health
Background:
- Hypertension is a major risk factor for stroke mortality, necessitating strict blood pressure (BP) control.
- Effective hypertension management in stroke patients is crucial for reducing secondary stroke events.
Purpose of the Study:
- To determine the prevalence of controlled blood pressure (BP) in stroke patients in Thailand.
- To evaluate current clinical practices for hypertension management among stroke patients.
Main Methods:
- A multicenter, cross-sectional, retrospective, observational study.
- Enrolled 558 stroke patients aged 45 years or older between February 2010 and January 2011.
- Confirmed stroke events via CT scan or MRI; collected demographic, medical, and clinical history.
Main Results:
- 49.1% of patients achieved controlled arterial BP (average 134.2/78.8 mm Hg) at enrollment.
- 73.8% received antihypertensive medications, with Angiotensin-Converting Enzyme Inhibitors (ACEIs) being most common (35.8%).
- Physicians cited insufficient antihypertensive use and lack of patient awareness as reasons for uncontrolled BP. Diabetes, hypertension stages, and ACEI use at discharge were associated with poorer BP control.
Conclusions:
- A significant proportion of stroke patients in Thailand do not meet BP targets, despite evidence supporting BP control benefits.
- Inadequate antihypertensive therapy and non-adherence to management guidelines likely contribute to poor BP control.
- Improved hypertension management strategies are needed for stroke patients in Thailand to reduce secondary stroke risk.
Background:
Direct correlation between stroke mortality and hypertension calls for a tight blood pressure (BP) control. Our study determined the prevalence of the BP control and evaluated current clinical practices on hypertension management in stroke patients in Thailand.
Methods:
This multicenter, cross-sectional, retrospective, observational study was carried out between February 2010 and January 2011 and enrolled stroke patients aged 45 years or older with ictus incidence 12,030 days before the enrollment. The events were confirmed by either computerized tomography scan or magnetic resonance imaging. Patient data including demographics, medical, and clinical history were collected.
Results:
At enrollment, 274 of 558 (49.1%) patients had controlled arterial BP with an average pressure of 134.220.4/78.812.8 mm Hg; 412 (73.8%) patients received antihypertensive medications and the most common use was angiotensin-converting enzyme inhibitors (ACEIs), reported in 200 (35.8%) patients. With questionnaire, insufficient antihypertensive use and lack of patients' awareness were the 2 most common reasons given by physicians for the patients' uncontrolled BP. Factors identified to have adverse association with the controlled BP at enrollment were diabetes at baseline, stage II hypertension, stage I hypertension, and the use of ACEIs at discharge (odds ratio of .18, .24, .30 [P < .001], and .53 [P = .009], respectively).
Conclusions:
Despite clinical evidence of the benefits of the BP control in reduction of secondary stroke events, a substantial number of stroke patients in Thailand do not achieve their BP targets, and this could possibly be a result of inadequate use of antihypertensive therapies and lack of compliance to BP management guidelines.
Related Concept Videos
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Errors occurring during blood pressure monitoring
Several factors...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Pre-Procedural Guidelines for Assessing Blood Pressure
Hypertension IV: Drug Therapy and Lifestyle Modifications
Hypertension and Regulation of Blood Pressure