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Nascent deep microbleeds and stroke recurrences

Toshio Imaizumi1, Shigeru Inamura1, Ikuhide Kohama1

  • 1Department of Neurosurgery, Kushiro City General Hospital, Hokkaido, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|June 27, 2013
PubMed
Abstract

Insights

Nascent deep cerebral microbleeds (MBs) detected by MRI are linked to increased stroke recurrence, especially deep intracerebral hemorrhages. This finding highlights MBs as a potential indicator for recurrent stroke risk.

Area of Science:

  • Neurology
  • Radiology
  • Cardiovascular Research

Background:

  • Cerebral microbleeds (MBs) on MRI correlate with cerebral microangiopathy severity.
  • Investigating the role of newly identified deep MBs in stroke recurrence is crucial.

Purpose of the Study:

  • To determine if nascent deep MBs contribute to stroke recurrence.
  • To assess the association between nascent deep MBs and the type of recurrent stroke.

Main Methods:

  • Prospective analysis of 508 patients treated for index strokes.
  • T2*-weighted MRI scans were used to count nascent deep MBs around 1 year post-stroke.
  • Kaplan-Meier curves and multivariate logistic regression were employed to analyze stroke recurrence and risk factors.

Main Results:

  • 256 nascent deep MBs were found in 116 patients.
  • Patients with nascent deep MBs had a significantly higher incidence of deep intracerebral hemorrhage (2.0% vs 0.4% per year).
  • Nascent deep MBs were significantly associated with stroke recurrences as deep intracerebral hemorrhages (OR 5.41, P = .007), even after adjusting for risk factors.

Conclusions:

  • Nascent deep MBs appear to be associated with an increased risk of stroke recurrence.
  • The presence of nascent deep MBs may specifically predict recurrent deep intracerebral hemorrhages.
Keywords:
Cerebral microbleedsintracerebral hemorrhagerecurrencerisk factorstroke

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