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Updated: May 10, 2026
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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Artificial lung and novel devices for respiratory support
Jeremiah T Martin1, Joseph B Zwischenberger
1Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky A.B. Chandler Medical Center, Lexington, Kentucky40536-0298, USA.
Seminars in Thoracic and Cardiovascular Surgery
|June 27, 2013
Summary
Extracorporeal membrane oxygenation (ECMO) is increasingly used as a bridge to lung transplantation, offering improved outcomes. Advances in technology now allow for ambulatory ECMO, also known as the "artificial lung," enhancing patient conditioning before transplant.
Area of Science:
- Cardiovascular and Respiratory System Research
- Biomedical Engineering
- Transplantation Science
Background:
- Extracorporeal membrane oxygenation (ECMO) has a long history in supporting respiratory function.
- Early use of ECMO for lung transplantation faced challenges with poor survival and complications.
- Recent advancements have revitalized ECMO as a critical tool in lung transplantation.
Purpose of the Study:
- To describe the historical evolution of ECMO in lung transplantation.
- To summarize current ECMO technologies and support strategies.
- To highlight the growing role of ECMO in preparing patients for lung transplant.
Main Methods:
- Review of historical data and literature on ECMO use in lung transplantation.
- Description of various ECMO modalities and technological advancements.
- Analysis of current approaches for ECMO patient management.
Main Results:
- Significant increase in ECMO utilization for lung transplantation over the last decade.
- Improved patient survival and outcomes with modern ECMO techniques.
- Development of ambulatory ECMO systems enabling patient mobility and conditioning.
Conclusions:
- ECMO is a vital and increasingly successful bridge to lung transplantation.
- Ambulatory ECMO, or the
- artificial lung,
- optimizes pre-transplant patient conditioning.
- Continued innovation in ECMO technology promises further improvements in lung transplant outcomes.
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