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Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

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Published on: September 14, 2017

Circulating endothelial progenitor cells in acromegaly.

G Bellastella¹, M I Maiorino, R Pivonello

¹Unit of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.

Journal of Endocrinological Investigation

|June 27, 2013

Summary

Acromegaly patients have increased levels of circulating endothelial progenitor cells (EPCs), which are crucial for vascular repair. These elevated EPCs, particularly those expressing KDR, are positively correlated with insulin-like growth factor I (IGF-I) levels.

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Area of Science:

Endocrinology
Vascular Biology
Cell Biology

Background:

Endothelial progenitor cells (EPCs) are vital for vascular repair and correlate with insulin-like growth factor I (IGF-I) in healthy individuals.
The levels and function of EPCs in acromegaly, a condition of excess growth hormone and IGF-I, remain uninvestigated.

Purpose of the Study:

To investigate the levels of circulating EPC phenotypes in patients with acromegaly.
To explore the relationship between EPC levels and IGF-I in acromegaly.

Main Methods:

A cross-sectional study involving 55 acromegalic patients and 65 healthy controls.
EPCs were quantified using flow cytometry, assessing markers like KDR, CD34, and CD133.
Insulin-like growth factor I (IGF-I) levels were measured by immunoradiometric assay.

Main Results:

Acromegalic patients exhibited significantly higher levels of KDR-expressing EPCs compared to controls.
Specific subsets, including CD34+KDR+, CD133+KDR+, and CD34+KDR+CD133+ cells, were markedly elevated in acromegaly patients.
A strong positive correlation was observed between CD34+KDR+CD133+ cell counts and IGF-I levels in acromegalic patients.

Conclusions:

Acromegalic patients demonstrate increased circulating EPCs expressing KDR.
These findings suggest a role for IGF-I in modulating EPC differentiation, specifically in the early stages.
Elevated EPCs in acromegaly may indicate an adaptive response to altered metabolic and vascular conditions.