Related Experiment Video
Updated: May 10, 2026
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Analysis of progression and recurrence of meningioma using (11)C-methionine PET
Hidetoshi Ikeda1, Naohiro Tsuyuguchi, Noritsugu Kunihiro
1Department of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan, hide-i@med.osaka-cu.ac.jp.
Objective:
The recurrence rate of meningioma after surgery is high, and progression is often observed. The risk factors for recurrence and progression are not clear. We evaluated the risk factors for recurrence and progression in meningioma using (11)C-methionine (MET) positron emission tomography (PET).
Methods:
Thirty-seven patients (mean follow-up, 80 months) with an intracranial meningioma were enrolled. MET PET was performed before treatment between 1995 and 2010, and patients were followed up in an out-patient clinic. Surgery was performed in 33 patients, and a wait-and-see approach was taken in four patients. We evaluated the extent of tumor resection, location, WHO grade, Ki-67 labeling index, and lesion to normal ratio (LN ratio) of MET uptake.
Results:
Six of the surgical cases had a recurrence, and two of the observation-only patients had tumor progression. A high LN ratio of MET uptake was a significant risk factor for recurrence and progression with univariate analysis. The area under the curve of receiver operating characteristic curve for the LN ratio of MET uptake was 0.754, and the optimal cutoff value was 3.18 (sensitivity 63 %, specificity 79 %). With multivariate analysis, a high LN ratio of MET uptake, non-gross total resection, and a high WHO grade were significant risk factors for progression and recurrence.
Conclusion:
A high LN ratio of MET uptake was a risk factor for tumor progression and recurrence. The advantage of MET PET is that it is not invasive and can easily be used to evaluate the whole tumor.
Insights
High methionine uptake on PET scans, indicated by a high lesion-to-normal ratio, predicts meningioma recurrence and progression. This non-invasive imaging can help assess the entire tumor risk.
Area of Science:
- Neuro-oncology
- Radiology
- Nuclear Medicine
Background:
- Meningioma recurrence and progression rates are high after surgery.
- Risk factors for meningioma recurrence and progression remain unclear.
- Positron emission tomography (PET) with (11)C-methionine (MET) offers a non-invasive imaging approach.
Purpose of the Study:
- To evaluate (11)C-methionine (MET) PET as a predictor of meningioma recurrence and progression.
- To identify risk factors for meningioma recurrence and progression.
Main Methods:
- Thirty-seven intracranial meningioma patients underwent MET PET before treatment.
- Follow-up averaged 80 months, with surgical or observational management.
- Evaluated factors included extent of resection, WHO grade, Ki-67, and MET uptake lesion-to-normal (LN) ratio.
Main Results:
- Six surgical cases recurred; two observation cases progressed.
- A high MET uptake LN ratio was a significant univariate risk factor.
- Multivariate analysis identified high LN ratio, non-gross total resection, and high WHO grade as significant risk factors for recurrence/progression.
Conclusions:
- Elevated MET uptake (high LN ratio) is a risk factor for meningioma progression and recurrence.
- MET PET is a valuable, non-invasive tool for whole-tumor risk assessment.
More Related Videos
Related Concept Videos
01:29Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET