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Related Experiment Video

Updated: May 10, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

Enhancers.

¹Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. kwcho@uci.edu

Wiley Interdisciplinary Reviews. Developmental Biology

|June 27, 2013

Summary

This summary is machine-generated.

Eukaryotic gene transcription is complex, involving transcription factors and DNA sequences. This review explores enhancer functions in metazoans, particularly their role in regulating gene expression during early development.

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Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

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Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

Area of Science:

Molecular Biology
Developmental Biology
Genomics

Background:

Eukaryotic gene transcription is a complex process regulated by transcription factors and DNA control sequences.
Recent genomic approaches have identified numerous enhancers and their functions.
Enhancers are crucial DNA elements that regulate gene expression.

Purpose of the Study:

To review the activities of enhancers in metazoans.
To discuss the role of enhancers in regulating gene expression during early development.
To highlight the importance of enhancers in developmental processes.

Main Methods:

Literature review of recent genomic studies.
Analysis of enhancer activity in metazoan models.
Focus on cis-regulatory elements and their modifications.

Main Results:

Identification of a vast number of enhancers and their diverse functions.
Enhancers play a critical role in orchestrating gene expression patterns.
Multiple modifications of transcription factors and DNA control sequences fine-tune gene regulation.

Conclusions:

Enhancers are key regulators of gene expression in metazoans.
Understanding enhancer function is vital for comprehending early development.
Further research into enhancer mechanisms will illuminate developmental processes.