Successful fluoxetine treatment of pathologic jealousy

A 39-year-old man suddenly became convinced that his wife had once been unfaithful to him, and soon thereafter he became depressed. Symptoms of depression responded to imipramine, but the jealousy did not. A trial of fluoxetine was attempted because of the obsessional nature of the jealousy. Fluoxetine 60 mg/day resulted in complete remission of the pathologic jealousy, consistent with the known efficacy of fluoxetine in obsessive compulsive disorder.