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Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
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[Protective effects of carnosine against closed head injury in mice]
Xuying Pei1, Kangxin Ni, You Zhou
1Zhejiang University School of Medicine, Hangzhou 310058, China.
Objective:
To investigate the protective effects of carnosine against experimental closed head injury (CHI) in mice.
Methods:
The CHI model was established by free-falling weight-drop. Carnosine (250 mg/kg or 500 mg/kg) was administered intraperitoneally 30 min before brain trauma, then q.d for 7 d; while normal saline was administrated for control group. The neurological defect was evaluated by neurological severity score (NSS) within 7 d; the survival rate and the histological alternations were observed.
Results:
Carnosine prevented the body weight loss of mice at dose of 500 mg/kg; significantly increased the survival rate, and reduced the neurological defect and histological damage at dose of 250 and 500 mg/kg.
Conclusion:
Carnosine can attenuate closed head injury in mice.
