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Updated: May 10, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
[Role of G protein-coupled receptor 17 in central nervous system injury]
Zhuang Zhang1, Erqing Wei, Yunbi Lu
1Key Laboratory of Medical Neurobiology of Ministry of Health, Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Abstract:
G-protein-coupled receptor 17 (GPR17), an originally orphan receptor, was identified as a new uracil nucleotides/cysteinyl leukotriene receptor. However, whether GPR17 is really classified as a leukotriene receptor is a matter deserving further investigation. GPR17 is involved in many physiological and pathological processes including brain injury, spinal cord injury, and oligodendrocyte differentiation. GPR17 may become a new therapeutic target in these diseases. In this article, the research progress on the pharmacology and pathophysiological roles of GPR17 is reviewed.
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