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Updated: May 10, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
The role of type 2 innate lymphoid cells in asthma
Ya-Jen Chang1, Rosemarie H DeKruyff, Dale T Umetsu
11.Harvard Medical School, Karp Labs, Room 10127, One Blackfan Circle, Boston, MA 02115, USA. dale.umetsu@childrens.harvard.edu; Ya-Jen Chang, Academia Sinica, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Abstract:
Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes that require innate rather than adaptive immunity. These innate pathways to asthma involve macrophages, neutrophils, as well as ILCs, newly described cell types that produce a variety of cytokines, including IL-5 and IL-13. We review the recent data regarding ILCs and their role in asthma.
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