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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Identification of human tissue cross-presenting dendritic cells: A new target for cancer vaccines
Muzlifah Haniffa1, Matthew Collin, Florent Ginhoux
1Institute of Cellular Medicine; Newcastle University; Newcastle upon Tyne, UK.
Abstract:
Dendritic cells (DCs) are a heterogeneous group of functionally specialized antigen-presenting cells. We recently characterized the human tissue cross-presenting DCs and aligned the human and mouse DC subsets. Our findings will facilitate the translation of murine DC studies to the human setting and aid the design of DC-based vaccine strategies for infection and cancer immunotherapy.
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