Related Experiment Video
Updated: May 10, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
CTLA-4 +49 A/G and -318 C/T polymorphisms and susceptibility to multiple sclerosis: a meta-analysis
1Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Objective:
The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G, and -318 C/T polymorphisms confer susceptibility to multiple sclerosis (MS).
Methods:
A meta-analysis of the associations between the CTLA-4 +49 A/G and -318 C/T polymorphisms and MS.
Results:
A total of 23 separate comparisons from 19 studies of the CTLA-4 +49 A/G polymorphism and 10 comparisons (8 studies) of the CTLA-4 -318 C/T polymorphism were considered. Meta-analysis showed no association between MS and the CTLA-4 +49G allele in the analysis of all study subjects (OR = 1.026, 95% CI = 0.967-1.089, p = 0.395). Stratification by ethnicity indicated no association between the CTLA-4 +49G allele and MS in Caucasians, Asians, or Arabs. Meta-analysis showed no association between RA and the CTLA-4 -318C allele in all study subjects (OR = 0.909, 95% CI = 0.704-1.175, p = 0.467). In addition, meta-analysis stratified by ethnicity revealed no association between MS and the CTLA-4 -318 C/T polymorphism in Caucasian, Asian, or Arab populations.
Conclusions:
This meta-analysis of published studies did not find an association between the CTLA-4 +49 A/G and -318 C/T polymorphisms and susceptibility to MS in Caucasian, Asian, and Arab populations.
Related Concept Videos
Multiple Sclerosis l: Introduction
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Single Nucleotide Polymorphisms-SNPs
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
