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Updated: May 10, 2026

08:44
Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers
Junjie Li1, Zhishen Ge, Shiyong Liu
1CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Abstract:
A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

