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Related Experiment Video

Updated: May 10, 2026

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
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Hyperferritinemia in dogs with splenic hemangiosarcoma.

Seishiro Chikazawa1, Yasutomo Hori, Fumio Hoshi

  • 1Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.

The Journal of Veterinary Medical Science
|June 28, 2013
PubMed
Summary

Serum ferritin levels are elevated in dogs with splenic hemangiosarcoma (HSA). While not specific, hyperferritinemia may serve as a sensitive indicator for splenic HSA in canine patients.

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Area of Science:

  • Veterinary Medicine
  • Canine Oncology
  • Biochemistry

Background:

  • Serum ferritin concentration is a known biomarker that elevates with various diseases in dogs.
  • Splenic masses are common in dogs, and early diagnosis is crucial for effective treatment.

Purpose of the Study:

  • To investigate serum ferritin levels in dogs with splenic masses.
  • To assess the diagnostic utility of serum ferritin for canine splenic hemangiosarcoma (HSA).

Main Methods:

  • Serum ferritin concentrations were measured using a sandwich ELISA assay.
  • Eleven dogs with hemangiosarcoma (HSA), six with hematoma, one with hemangioma, and three with lymphoma were included.

Main Results:

  • All dogs diagnosed with HSA exhibited serum ferritin concentrations exceeding the normal limit.

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  • Elevated serum ferritin was also noted in some cases of hematoma, hemangioma, and lymphoma.

    • Conclusions:

    • Hyperferritinemia is not exclusively indicative of splenic HSA but shows potential as a sensitive diagnostic marker.
    • Further research is warranted to fully evaluate the clinical usefulness of serum ferritin testing in dogs with splenic HSA.